Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue

Highlights ► Visceral fat has significantly higher VEGF, CD8+ and NKT cells than subcutaneous fat. ► VEGF levels in serum and vACM is significantly higher in viscerally obese patients. ► vACM from viscerally obese patients induces significant tumour cell proliferation. ► Neutralising VEGF but not IL...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2011-12, Vol.312 (1), p.62-72
Hauptverfasser:	Lysaght, J, van der Stok, E.P, Allott, E.H, Casey, R, Donohoe, C.L, Howard, J.M, McGarrigle, S.A, Ravi, N, Reynolds, J.V, Pidgeon, G.P
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma adipose tissue adiposity Adult Aged Aged, 80 and over Blood pressure Body fat Cell culture Cell Growth Processes - physiology cell proliferation Central obesity Colorectal cancer colorectal neoplasms Cytokines Diabetes Female Gastro-intestinal malignancy Hematology, Oncology and Palliative Medicine Hospitals Humans Inflammation Inflammation - pathology interleukin-6 Intra-Abdominal Fat - pathology Male Medical research Middle Aged Mortality Neoplasms - pathology neutralization Obesity Obesity - pathology patients Rodents Studies Subcutaneous Fat - pathology Surgery T-lymphocytes Tumour cell proliferation Vascular Endothelial Growth Factor A - metabolism Visceral adipose tissue
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Visceral fat has significantly higher VEGF, CD8+ and NKT cells than subcutaneous fat. ► VEGF levels in serum and vACM is significantly higher in viscerally obese patients. ► vACM from viscerally obese patients induces significant tumour cell proliferation. ► Neutralising VEGF but not IL-6 in vACM significantly reduces tumour cell proliferation. ► VEGF may represent a potential therapeutic target in obese cancer patients.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.07.034