ERas Enhances Resistance to CPT-11 in Gastric Cancer

We have reported that embryonic stem cell-expressed Ras (ERas) is expressed in human gastric cancer and is associated with its tumorigenicity. Here, we asked whether ERas plays a role in resistance to chemotherapy in gastric cancer. To assess the cytotoxicity of chemotherapeutic agents, ERas-overexp...

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Veröffentlicht in:	Anticancer research 2011-10, Vol.31 (10), p.3353-3360
Hauptverfasser:	KUBOTA, Eiji, KATAOKA, Hiromi, TANIDA, Satoshi, KAMIYA, Takeshi, AOYAMA, Mineyoshi, ASAI, Kiyofumi, JOH, Takashi, TANAKA, Mamoru, OKAMOTO, Yasuyuki, EBI, Masahide, HIRATA, Yoshikazu, MURAKAMI, Kenji, MIZOSHITA, Tsutomu, SHIMURA, Takaya, MORI, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Camptothecin - analogs & derivatives Camptothecin - pharmacology Camptothecin - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects DNA - metabolism DNA Topoisomerases, Type I - metabolism Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Humans Inhibitory Concentration 50 Medical sciences Models, Biological NF-kappa B - metabolism Protein Binding - drug effects ras Proteins - metabolism Sirolimus - pharmacology Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Up-Regulation - drug effects
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Zusammenfassung:	We have reported that embryonic stem cell-expressed Ras (ERas) is expressed in human gastric cancer and is associated with its tumorigenicity. Here, we asked whether ERas plays a role in resistance to chemotherapy in gastric cancer. To assess the cytotoxicity of chemotherapeutic agents, ERas-overexpressing human gastric cancer GCIY cells were exposed to anticancer agents, including CPT-11 and inhibitor of mammalian target of rapamycin (mTOR). We also investigated the mechanisms by which ERas induces chemoresistance. ERas-overexpressing clones were significantly more resistant to CPT-11 than were the control (p
ISSN:	0250-7005 1791-7530