Effects of GH assay standardization on evaluation of treatment outcomes for acromegaly in Japan

In Japan, the growth hormone (GH) assay has been standardized since April 2005 through use of a uniform recombinant human GH (rhGH) standard. Since then, GH values measured using the rhGH standard have been approximately 40% lower than previous values measured using kit standards based on the WHO st...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2011, Vol.58(9), pp.777-782
Hauptverfasser:	Fukuda, Izumi, Kurimoto, Makiko, Tanaka, Satoshi, Yamakado, Yu, Muraoka, Toko, Takano, Kazue, Hizuka, Naomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly Acromegaly - blood Acromegaly - surgery Adult Aged Blood Glucose - analysis Diabetes mellitus Female GH standardization Glucose Tolerance Test Human Growth Hormone - blood Humans Immunoenzyme Techniques - methods Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor I - metabolism Japan Male Middle Aged Recombinant Proteins - chemistry Retrospective Studies Statistics, Nonparametric Treatment Outcome Young Adult
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Beschreibung
Zusammenfassung:	In Japan, the growth hormone (GH) assay has been standardized since April 2005 through use of a uniform recombinant human GH (rhGH) standard. Since then, GH values measured using the rhGH standard have been approximately 40% lower than previous values measured using kit standards based on the WHO standards for hGH of pituitary origin. However, the Japanese criteria for evaluating treatment outcomes for acromegaly have remained the same: a nadir GH during a 75 g OGTT
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.K11E-099