Bypassing GPCRs with Chemical Dimerizers

Bypassing GPCRs with Chemical Dimerizers

G protein-coupled receptors (GPCRs) activate heterotrimeric G protein complexes. In this issue, Putyrski and Schultz (2011) describe a rapamycin-based system to bypass the GPCR by direct activation of a specific heterotrimeric G protein subunit, which induces downstream signaling cascades.

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Veröffentlicht in:Chemistry & biology 2011-09, Vol.18 (9), p.1067-1068
Hauptverfasser: Goedhart, J., Gadella, T.W.J.
Format: Artikel
Sprache:eng
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Zusammenfassung:G protein-coupled receptors (GPCRs) activate heterotrimeric G protein complexes. In this issue, Putyrski and Schultz (2011) describe a rapamycin-based system to bypass the GPCR by direct activation of a specific heterotrimeric G protein subunit, which induces downstream signaling cascades.
ISSN:1074-5521
1879-1301
DOI:10.1016/j.chembiol.2011.09.004