Remarkably High Reactivity of Pd(OAc)2/Pyridine Catalysts: Nondirected CH Oxygenation of Arenes

Remarkably High Reactivity of Pd(OAc)2/Pyridine Catalysts: Nondirected CH Oxygenation of Arenes

Less is more: The rational optimization and general applicability of the catalytic system Pd(OAc)2/pyridine is described (see scheme). The catalyst shows excellent reactivity in the CH oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyrid...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-09, Vol.50 (40), p.9409-9412
Hauptverfasser: Emmert, Marion H., Cook, Amanda K., Xie, Yushu J., Sanford, Melanie S.
Format: Artikel
Sprache:eng
Schlagworte:
CH activation
homogeneous catalysis
N ligands
oxidation
palladium
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Zusammenfassung:Less is more: The rational optimization and general applicability of the catalytic system Pd(OAc)2/pyridine is described (see scheme). The catalyst shows excellent reactivity in the CH oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2 alone.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201103327