Tumor-Targeting Gold Particles for Dual Computed Tomography/Optical Cancer Imaging

Tumor-Targeting Gold Particles for Dual Computed Tomography/Optical Cancer Imaging

Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X‐ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2011-09, Vol.50 (40), p.9348-9351
Hauptverfasser: Sun, In-Cheol, Eun, Dae-Kyung, Koo, Heebeom, Ko, Chang-Yong, Kim, Han-Sung, Yi, Dong Kee, Choi, Kuiwon, Kwon, Ick Chan, Kim, Kwangmeyung, Ahn, Cheol-Hee
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chitosan - chemistry
Computed tomography
Contrast Media - chemistry
Gold
Humans
imaging agents
Matrix Metalloproteinase 2 - chemistry
Matrix Metalloproteinase 2 - metabolism
Metal Nanoparticles
Mice
nanoparticles
Neoplasms - diagnosis
Peptides - chemistry
Peptides - metabolism
Spectrophotometry, Ultraviolet
Spectroscopy, Near-Infrared
Substrate Specificity
Surface Plasmon Resonance
Tomography, X-Ray Computed - methods
Xenograft Model Antitumor Assays
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X‐ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201102892