Lidocaine Attenuates the Development of Diabetic-Induced Tactile Allodynia by Inhibiting Microglial Activation

Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy. Although the analgesic effect of lidocaine through suppression of microglial activation has been implicated in the development of injury-induced neuropathic pain, its mechanism of action in diabetes-induc...

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Veröffentlicht in:	Anesthesia and analgesia 2011-10, Vol.113 (4), p.941-946
Hauptverfasser:	Suzuki, Naoko, Hasegawa-Moriyama, Maiko, Takahashi, Yoshika, Kamikubo, Yuji, Sakurai, Takashi, Inada, Eiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Local - administration & dosage Anesthetics, Local - pharmacology Animals Behavior, Animal - drug effects Biological and medical sciences Cells, Cultured Chemokine CCL2 - metabolism Chemotaxis - drug effects Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetic Neuropathies - etiology Diabetic Neuropathies - metabolism Diabetic Neuropathies - physiopathology Diabetic Neuropathies - prevention & control Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - physiopathology Hyperalgesia - prevention & control Infusions, Parenteral Interferon-gamma - metabolism Interleukin-1beta - metabolism Lidocaine - administration & dosage Lidocaine - pharmacology Male Medical sciences Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Nitric Oxide Synthase Type II - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Pain Measurement Pain Threshold - drug effects Phosphorylation Posterior Horn Cells - drug effects Posterior Horn Cells - metabolism Time Factors
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