Basic Microbiological Techniques Used in Antibacterial Drug Discovery

In vitro assessment of activity is crucial to the development of antibacterial agents. Several basic clinical microbiology procedures for this evaluation are provided in this unit, including determination of the minimum inhibitor concentration (MIC), kill curves, and synergy testing. These technique...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current Protocols in Pharmacology 2006, Vol.31 (1), p.13A.3.1-13A.3.22
Hauptverfasser:	Motyl, Mary, Dorso, Karen, Barrett, John, Giacobbe, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Culture Media Drug Discovery kill curves MIC Microbial Sensitivity Tests Microbiological Techniques post‐antibiotic effect synergy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In vitro assessment of activity is crucial to the development of antibacterial agents. Several basic clinical microbiology procedures for this evaluation are provided in this unit, including determination of the minimum inhibitor concentration (MIC), kill curves, and synergy testing. These techniques yield information on in vitro efficacy, cidal‐versus‐static activity, and the potential for synergy with other agents.
ISSN:	1934-8282 1934-8290
DOI:	10.1002/0471141755.ph13a03s31