Prevention of paracentesis-induced circulatory dysfunction in cirrhosis: Standard vs half albumin doses. A prospective, randomized, unblinded pilot study

Prevention of paracentesis-induced circulatory dysfunction in cirrhosis: Standard vs half albumin doses. A prospective, randomized, unblinded pilot study

Highlights ► PICD is a frequent and harmful complication of large volume paracentesis in cirrhosis. ► The efficacy of albumin (8 g/L of ascites removed) in preventing it is demonstrated. ► Albumin has high costs and limited availability. ► Half doses (4 g/L) were effective in preventing PICD and its...

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Veröffentlicht in:Digestive and liver disease 2011-11, Vol.43 (11), p.881-886
Hauptverfasser: Alessandria, Carlo, Elia, Chiara, Mezzabotta, Lavinia, Risso, Alessandro, Andrealli, Alida, Spandre, Maurizio, Morgando, Anna, Marzano, Alfredo, Rizzetto, Mario
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Albumin
Albumins - administration & dosage
Albumins - therapeutic use
Ascites
Ascites - complications
Ascites - therapy
Blood Pressure
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Circulatory dysfunction
Cirrhosis
Female
Gastroenterology and Hepatology
Humans
Hyponatremia - etiology
Kaplan-Meier Estimate
Liver Cirrhosis - complications
Logistic Models
Male
Middle Aged
Multivariate Analysis
Paracentesis
Paracentesis - adverse effects
Pilot Projects
Plasma Substitutes - administration & dosage
Plasma Substitutes - therapeutic use
Recurrence
Renal Insufficiency - etiology
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Zusammenfassung:Highlights ► PICD is a frequent and harmful complication of large volume paracentesis in cirrhosis. ► The efficacy of albumin (8 g/L of ascites removed) in preventing it is demonstrated. ► Albumin has high costs and limited availability. ► Half doses (4 g/L) were effective in preventing PICD and its clinical complications. ► Achievement: significant costs reduction in the management of ascites in cirrhosis.
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2011.06.001