Detection of Drugs of Abuse in Saliva by Surface-Enhanced Raman Spectroscopy (SERS)

Detection of Drugs of Abuse in Saliva by Surface-Enhanced Raman Spectroscopy (SERS)

Eighty drugs of abuse and metabolites were successfully measured by surface-enhanced Raman spectroscopy (SERS) using gold- and silver-doped sol-gels immobilized in glass capillaries. A method was developed that provided consistent detection of 50 ppb cocaine in saliva in a focused study. This genera...

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Veröffentlicht in:Applied spectroscopy 2011-09, Vol.65 (9), p.1004-1008
Hauptverfasser: Inscore, Frank, Shende, Chetan, Sengupta, Atanu, Huang, Hermes, Farquharson, Stuart
Format: Artikel
Sprache:eng
Schlagworte:
Gold - chemistry
Humans
ROC Curve
Saliva - chemistry
Silver - chemistry
Spectrum Analysis, Raman - methods
Street Drugs - analysis
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Zusammenfassung:Eighty drugs of abuse and metabolites were successfully measured by surface-enhanced Raman spectroscopy (SERS) using gold- and silver-doped sol-gels immobilized in glass capillaries. A method was developed that provided consistent detection of 50 ppb cocaine in saliva in a focused study. This general method was successfully applied to the detection of a number of additional drugs in saliva, such as amphetamine, diazepam, and methadone.
ISSN:0003-7028
1943-3530
0003-7028
DOI:10.1366/11-06310