Adaptive laboratory evolution — harnessing the power of biology for metabolic engineering
Highlights ► Adaptive laboratory evolution (ALE) as a tool for metabolic engineering. ► Latent pathway activation by ALE. ► ALE has successfully been used to optimize the phenotype of a microorganism. ► Adaptation to changing environments by ALE.
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| Veröffentlicht in: | Current opinion in biotechnology 2011-08, Vol.22 (4), p.590-594 |
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| container_issue | 4 |
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| container_title | Current opinion in biotechnology |
| container_volume | 22 |
| creator | Portnoy, Vasiliy A Bezdan, Daniela Zengler, Karsten |
| description | Highlights ► Adaptive laboratory evolution (ALE) as a tool for metabolic engineering. ► Latent pathway activation by ALE. ► ALE has successfully been used to optimize the phenotype of a microorganism. ► Adaptation to changing environments by ALE. |
| doi_str_mv | 10.1016/j.copbio.2011.03.007 |
| format | Article |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Directed Molecular Evolution enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism evolution genetic variation Internal Medicine metabolic engineering Metabolic Networks and Pathways microorganisms mutation regulator genes Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism |
| title | Adaptive laboratory evolution — harnessing the power of biology for metabolic engineering |
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