Adaptive laboratory evolution — harnessing the power of biology for metabolic engineering

Highlights ► Adaptive laboratory evolution (ALE) as a tool for metabolic engineering. ► Latent pathway activation by ALE. ► ALE has successfully been used to optimize the phenotype of a microorganism. ► Adaptation to changing environments by ALE.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in biotechnology 2011-08, Vol.22 (4), p.590-594
Hauptverfasser:	Portnoy, Vasiliy A, Bezdan, Daniela, Zengler, Karsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Directed Molecular Evolution enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism evolution genetic variation Internal Medicine metabolic engineering Metabolic Networks and Pathways microorganisms mutation regulator genes Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► Adaptive laboratory evolution (ALE) as a tool for metabolic engineering. ► Latent pathway activation by ALE. ► ALE has successfully been used to optimize the phenotype of a microorganism. ► Adaptation to changing environments by ALE.
ISSN:	0958-1669 1879-0429
DOI:	10.1016/j.copbio.2011.03.007