Palladium(II)-Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak-Coordination Approach

Palladium(II)-Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak-Coordination Approach

Finally, a choice! A highly selective palladium(II)‐catalyzed ortho‐monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6‐tetrafluoro‐4‐(trifluoromethyl)phenyl). Simple modification of this protocol allows for a choice between mono‐ and di...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-09, Vol.50 (39), p.9081-9084
Hauptverfasser: Chan, Kelvin S. L., Wasa, Masayuki, Wang, Xisheng, Yu, Jin-Quan
Format: Artikel
Sprache:eng
Schlagworte:
auxiliaries
Benzamides - chemistry
Benzoates - chemistry
benzoic acids
Catalysis
CH activation
fluorination
Fluorine - chemistry
Palladium
Palladium - chemistry
weak coordination
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Zusammenfassung:Finally, a choice! A highly selective palladium(II)‐catalyzed ortho‐monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6‐tetrafluoro‐4‐(trifluoromethyl)phenyl). Simple modification of this protocol allows for a choice between mono‐ and difluorination. The mono‐ and difluorinated benzoic acid derivatives are valuable in the pharmaceutical and agrochemical industries.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201102985