Screw-Sense Control of Helical Oligopeptides Containing Equal Amounts of L- and D-Amino Acids

Residue order is important! The preferred secondary structures of Boc‐(L‐Leu‐D‐Leu‐Aib)n‐OMe containing equal amounts of L‐ and D‐Leu have been investigated and the results show that these residues form right‐handed (P) α helices in both solution and crystalline states (see picture)....

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Veröffentlicht in:	Chemistry : a European journal 2011-09, Vol.17 (40), p.11107-11109
Hauptverfasser:	Demizu, Yosuke, Doi, Mitsunobu, Sato, Yukiko, Tanaka, Masakazu, Okuda, Haruhiro, Kurihara, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Amino Acids - chemistry Chemistry conformational analysis Crystal structure Crystallography, X-Ray Helical Molecular Structure Oligopeptides - chemistry peptides Pictures Protein Structure, Secondary Residues screw-sense control Sequence Analysis, Protein Stereoisomerism X-ray crystallography
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Beschreibung
Zusammenfassung:	Residue order is important! The preferred secondary structures of Boc‐(L‐Leu‐D‐Leu‐Aib)n‐OMe containing equal amounts of L‐ and D‐Leu have been investigated and the results show that these residues form right‐handed (P) α helices in both solution and crystalline states (see picture).
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.201101809