Clinical utility of dual-energy CT for evaluation of tophaceous gout

Although diagnosing gout generally is straightforward, atypical disease may present a challenge if it is associated with unusual symptoms or sites, discordant serum urate level, or mimics of gout. Dual-energy computed tomography (CT) may be used to differentiate urate crystals from calcium by using...

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Veröffentlicht in:Radiographics 2011-09, Vol.31 (5), p.1365-1375
Hauptverfasser: Desai, Madhura A, Peterson, Jeffrey J, Garner, Hillary Warren, Kransdorf, Mark J
Format: Artikel
Sprache:eng
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Zusammenfassung:Although diagnosing gout generally is straightforward, atypical disease may present a challenge if it is associated with unusual symptoms or sites, discordant serum urate level, or mimics of gout. Dual-energy computed tomography (CT) may be used to differentiate urate crystals from calcium by using specific attenuation characteristics, which may help diagnose gout. In patients with known tophaceous gout, dual-energy CT may be used for serial volumetric quantification of subclinical tophi to evaluate response to treatment. Given the utility of dual-energy CT in challenging cases and its ability to provide an objective outcomes measure in patients with tophaceous gout, dual-energy CT promises to be a unique and clinically relevant modality in the diagnosis and management of gout.
ISSN:0271-5333
1527-1323
DOI:10.1148/rg.315115510