Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm

Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm

We demonstrate a method to estimate the concentrations of water and lipid in scattering media such as biological tissues with diffuse optical spectra acquired over the range of 900 to 1600 nm. Estimations were performed by fitting the spectra to a model of light propagation in scattering media deriv...

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Veröffentlicht in:Journal of Biomedical Optics 2010-05, Vol.15 (3), p.037015-037015
Hauptverfasser: Nachabe, Rami, Hendriks, Benno H. W, Desjardins, Adrien E, van der Voort, Marjolein, van der Mark, Martin B, Sterenborg, Henricus J. C. M
Format: Artikel
Sprache:eng
Schlagworte:
Diffusion
Diffusion theory
Emulsions
Lipids
Mathematical models
Media
Scattering
Spectra
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Zusammenfassung:We demonstrate a method to estimate the concentrations of water and lipid in scattering media such as biological tissues with diffuse optical spectra acquired over the range of 900 to 1600 nm. Estimations were performed by fitting the spectra to a model of light propagation in scattering media derived from diffusion theory. To validate the method, spectra were acquired from tissue phantoms consisting of lipid and water emulsions and swine tissues ex vivo with a two-fiber probe.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.3454392