N-heterocyclic carbene-catalyzed aza-Michael addition

N-heterocyclic carbene-catalyzed aza-Michael addition

Aza-Michael addition of amines, including aromatic and aliphatic amines, with α, β-unsaturated ketones was realized employing N-Heterocyclic Carbene (NHC) as organocatalyst, yielding β-amino ketones with up to 98% yield.

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Veröffentlicht in:Organic & biomolecular chemistry 2011-10, Vol.9 (19), p.6715-6720
Hauptverfasser: Kang, Qiang, Zhang, Yugen
Format: Artikel
Sprache:eng
Schlagworte:
Amines - chemistry
Catalysis
Heterocyclic Compounds - chemistry
Ketones - chemical synthesis
Ketones - chemistry
Methane - analogs & derivatives
Methane - chemistry
Molecular Structure
Stereoisomerism
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Zusammenfassung:Aza-Michael addition of amines, including aromatic and aliphatic amines, with α, β-unsaturated ketones was realized employing N-Heterocyclic Carbene (NHC) as organocatalyst, yielding β-amino ketones with up to 98% yield.
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob05429e