The social aspects of EMT-MET plasticity

Although the importance of epithelial to mesenchymal transition (EMT) is acknowledged in tumor metastasis, the contribution of the reverse process—MET—to cancer progression has been unclear. A new study shows that the miR-200 family regulates MET and metastatic colonization in breast cancer, suggest...

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Veröffentlicht in:	Nature medicine 2011-09, Vol.17 (9), p.1048-1049
Hauptverfasser:	Thompson, E W, Haviv, I
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/80/84/2176 692/699/67/1347 692/699/67/322 Animals Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cellular biology Development and progression Female Gene expression Gene Expression Regulation, Neoplastic - physiology Genetic aspects Humans Infectious Diseases Metabolic Diseases Metastasis MicroRNAs - metabolism Molecular Medicine Neoplasm Metastasis - physiopathology Neurosciences news-and-views Physiological aspects Plasticity Risk factors Stem cells Vesicular Transport Proteins - metabolism
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Zusammenfassung:	Although the importance of epithelial to mesenchymal transition (EMT) is acknowledged in tumor metastasis, the contribution of the reverse process—MET—to cancer progression has been unclear. A new study shows that the miR-200 family regulates MET and metastatic colonization in breast cancer, suggesting that flexible transitions between EMT and MET, or epithelial-mesenchymal plasticity, may be crucial at different stages of metastasis (pages 1101–1108 ).
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.2437