Sea urchin eggs in the acid reign

Abstract Sea urchin eggs have been an indispensable model system for studying egg activation and ionic signalling for at least a century. Instrumental in the discovery of two Ca2+ -mobilizing second messengers, cyclic ADP-ribose and NAADP, the sea urchin has revolutionized cell biology for all phyla...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2011-08, Vol.50 (2), p.147-156
1. Verfasser:	Morgan, Anthony J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic Ca 2+ stores Acids - metabolism Advanced Basic Science Animals Antiporters - metabolism Ca 2 cADPR Calcium - metabolism Calcium Channels - metabolism Calcium Signaling Calcium-Transporting ATPases - metabolism Cation Transport Proteins - metabolism Cortical granules Cyclic ADP-Ribose - metabolism Cytoplasmic Vesicles - metabolism Echinoidea Endosomes Fertilization Hydrogen-Ion Concentration IP3 Lysosomes Marine NAADP NADP - analogs & derivatives NADP - metabolism Ovum - metabolism Sea urchin egg Sea Urchins - metabolism TPC Two-pore channel Yolk platelets
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Beschreibung
Zusammenfassung:	Abstract Sea urchin eggs have been an indispensable model system for studying egg activation and ionic signalling for at least a century. Instrumental in the discovery of two Ca2+ -mobilizing second messengers, cyclic ADP-ribose and NAADP, the sea urchin has revolutionized cell biology for all phyla. This review attempts to summarize what we currently know about egg acidic vesicles in the context of Ca2+ signalling. The dynamics of Ca2+ storage, Ca2+ mobilization, proton fluxes and two-pore channels will be discussed.
ISSN:	0143-4160 1532-1991
DOI:	10.1016/j.ceca.2010.12.007