C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbils

Highlights ► C-Phycocyanin (C-PC) prevents gerbil brain ischemia–reperfusion injury (IRI). ► C-PC reduces infarct volume and hippocampal cell death induced by IRI. ► Neurological outcome and survival correlated with histological findings. ► C-PC antioxidant, anti-inflammatory and immuno-modulatory p...

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Veröffentlicht in:	Brain research bulletin 2011-08, Vol.86 (1), p.42-52
Hauptverfasser:	Pentón-Rol, Giselle, Marín-Prida, Javier, Pardo-Andreu, Gilberto, Martínez-Sánchez, Gregorio, Acosta-Medina, Emilio Felino, Valdivia-Acosta, Alain, Lagumersindez-Denis, Nielsen, Rodríguez-Jiménez, Efraín, Llópiz-Arzuaga, Alexey, López-Saura, Pedro Antonio, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Behavior, Animal - drug effects Brain Ischemia - mortality Brain Ischemia - pathology Brain Ischemia - physiopathology C-Phycocyanin Gerbil Gerbillinae Global cerebral ischemia/reperfusion Hippocampus - cytology Hippocampus - drug effects Hippocampus - pathology Humans Lipid Peroxidation - drug effects Male Malondialdehyde - metabolism Motor Activity - drug effects Motor Activity - physiology Neurology Neurons - drug effects Neurons - pathology Neuroprotection Neuroprotective Agents - pharmacology Oxidation-Reduction Oxidative Stress Phycocyanin - pharmacology Random Allocation Reperfusion Injury - pathology Reperfusion Injury - prevention & control Survival Rate
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Zusammenfassung:	Highlights ► C-Phycocyanin (C-PC) prevents gerbil brain ischemia–reperfusion injury (IRI). ► C-PC reduces infarct volume and hippocampal cell death induced by IRI. ► Neurological outcome and survival correlated with histological findings. ► C-PC antioxidant, anti-inflammatory and immuno-modulatory properties support protection. ► First report on C-PC protection in brain IRI shows potential for stroke therapy.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2011.05.016