Molluscicidal activity of cardiac glycosides from Nerium indicum against Pomacea canaliculata and its implications for the mechanisms of toxicity

Highlights ► Cardiac glycosides are an effective molluscicide against GAS. ► LC50 value of cardiac glycosides is time dependent. ► Glycogen content in GAS decrease significantly under cardiac glucosides stress. ► Exposure to 4.71 mg/L cardiac glycosides for 72 h, synthesis of EST almost cease. ► Car...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2011-09, Vol.32 (2), p.226-232
Hauptverfasser:	Dai, Lingpeng, Wang, Wanxian, Dong, Xinjiao, Hu, Renyong, Nan, Xuyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - analogs & derivatives Acetaldehyde - toxicity Animals Cardiac glycosides Cardiac Glycosides - toxicity Cholinesterases - metabolism Emergency Glycogen - metabolism Isoenzymes - metabolism Lethal Dose 50 Mollusca Molluscacides - toxicity Molluscicidal activity Nerium - anatomy & histology Nerium - chemistry Nerium indicum Plant Extracts - chemistry Plant Extracts - toxicity Plant Leaves - chemistry Pomacea canaliculata Snails - anatomy & histology Snails - drug effects Snails - physiology Toxicological mechanisms
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Zusammenfassung:	Highlights ► Cardiac glycosides are an effective molluscicide against GAS. ► LC50 value of cardiac glycosides is time dependent. ► Glycogen content in GAS decrease significantly under cardiac glucosides stress. ► Exposure to 4.71 mg/L cardiac glycosides for 72 h, synthesis of EST almost cease. ► Cardiac glucosides impair normal physiological metabolism and cause GAS death.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2011.05.007