Protection of myocardial mitochondria against oxidative damage by selenium-containing abzyme m4G3

Selenium-containing abzyme (m4G3) was prepared and its protection of myocardial mitochondria against oxidative damage was studied using the swelling of mitochondria, quantity of lipid peroxidation products, and change in cytochrome-c oxidase activity as a measure of mitochondrial damage. The results...

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Veröffentlicht in:	Applied biochemistry and biotechnology 1999-12, Vol.82 (3), p.167-173
Hauptverfasser:	QI, D.-H, LUO, G.-M, LI ZHOU, YANG, T.-S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Catalytic - pharmacology Biological and medical sciences Biotechnology Cattle Electron Spin Resonance Spectroscopy Electron Transport Complex IV - metabolism Free Radicals Fundamental and applied biological sciences. Psychology Glutathione Peroxidase - pharmacology Lipid Peroxidation Lipids Malondialdehyde - metabolism Methods. Procedures. Technologies Mitochondria Mitochondria, Heart - enzymology Mitochondria, Heart - metabolism Oxidative Stress - drug effects Peroxidation Protein engineering Selenium Selenium - pharmacology selenium-containing abzymes Studies Time Factors Xanthine Oxidase - metabolism
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Beschreibung
Zusammenfassung:	Selenium-containing abzyme (m4G3) was prepared and its protection of myocardial mitochondria against oxidative damage was studied using the swelling of mitochondria, quantity of lipid peroxidation products, and change in cytochrome-c oxidase activity as a measure of mitochondrial damage. The results showed that m4G3 could inhibit mitochondrial damage caused by the hypoxanthine-xanthine oxidase system in vitro. Electronic spin resonance (ESR) studies demonstrated that m4G3 could decrease the amount of free radicals generated in the damage system.
ISSN:	0273-2289 1559-0291 0273-2289
DOI:	10.1385/abab:82:3:167