Modulation of Cytokine Secretion and Oxidative Metabolism of Innate Immune Effectors by Rhodococcus Biosurfactant

The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-11, Vol.149 (6), p.734-738
Hauptverfasser:	Chereshnev, V. A, Gein, S. V, Baeva, T. A, Galkina, T. V, Kuyukina, M. S, Ivshina, I. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine biosurfactants Cell Biology Cell culture chemiluminescence Cytokines Cytokines - metabolism glycolipid biosurfactant Glycolipids Immunity Immunity, Innate Interleukin 10 Interleukin 12 Interleukin 18 interleukin-10, interleukin-18, and interleukin-12 Internal Medicine Laboratory Medicine Leukocytes (mononuclear) Lipopolysaccharides Membrane lipids Monocytes Oxidation-Reduction Oxidative metabolism Pathology Pharmaceutical industry Physiological aspects Plant lipids Reactive oxygen species Rhodococcus Rhodococcus - physiology Rhodococcus rubber Rhodococcus ruber Sugars Surface-Active Agents - pharmacology
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Zusammenfassung:	The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-1039-4