No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

We sought to investigate the contribution of extended runs of homozygosity in a genome‐wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited...

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2011-12, Vol.156B (7), p.764-771
Hauptverfasser:	Sims, Rebecca, Dwyer, Sarah, Harold, Denise, Gerrish, Amy, Hollingworth, Paul, Chapman, Jade, Jones, Nicola, Abraham, Richard, Ivanov, Dobril, Pahwa, Jaspreet Singh, Moskvina, Valentina, Dowzell, Kimberley, Thomas, Charlene, Stretton, Alexandra, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuiness, Bernadette, Todd, Stephen, Johnston, Janet A., Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Jones, Lesley, Holmans, Peter A., O'Donovan, Michael, Owen, Michael J., Williams, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer's disease Biological and medical sciences Case-Control Studies Chromosomes, Human, Pair 8 - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genes - genetics Genetic Predisposition to Disease Genome-Wide Association Study Geriatrics Homozygote Humans Male Medical genetics Medical sciences Neurodegenerative diseases Neurology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry runs of homozygosity Single-nucleotide polymorphism
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Zusammenfassung:	We sought to investigate the contribution of extended runs of homozygosity in a genome‐wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease. © 2011 Wiley‐Liss, Inc.
ISSN:	1552-4841 1552-485X 1552-485X
DOI:	10.1002/ajmg.b.31216