Aptamer-Based Switchable Nanovalves for Stimuli-Responsive Drug Delivery

Molecular gates: A new approach in developing controlled drug‐delivery systems using aptamers as nanovalves is presented. For the proof of principle, mesoporous silica nanoparticles were modified with a hairpin form of ATP‐binding DNA, which allows encapsulation and release of guest molecules contro...

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Veröffentlicht in:	Chemistry : a European journal 2011-08, Vol.17 (36), p.9893-9896
Hauptverfasser:	Ozalp, Veli C, Schafer, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	aptamers Aptamers, Nucleotide - chemistry Chemistry Control systems Deoxyribonucleic acid Drug Carriers - chemistry drug delivery Drug Delivery Systems Encapsulation Fluorescein - chemistry Fluorescein - pharmacokinetics Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacokinetics Gates molecular gates Nanoparticles Nanostructure Nanostructures - chemistry nanovalves Silicon dioxide Silicon Dioxide - chemistry stimuli-responsive nanoparticles
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