Aptamer-Based Switchable Nanovalves for Stimuli-Responsive Drug Delivery

Molecular gates: A new approach in developing controlled drug‐delivery systems using aptamers as nanovalves is presented. For the proof of principle, mesoporous silica nanoparticles were modified with a hairpin form of ATP‐binding DNA, which allows encapsulation and release of guest molecules contro...

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Veröffentlicht in:	Chemistry : a European journal 2011-08, Vol.17 (36), p.9893-9896
Hauptverfasser:	Ozalp, Veli C, Schafer, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	aptamers Aptamers, Nucleotide - chemistry Chemistry Control systems Deoxyribonucleic acid Drug Carriers - chemistry drug delivery Drug Delivery Systems Encapsulation Fluorescein - chemistry Fluorescein - pharmacokinetics Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacokinetics Gates molecular gates Nanoparticles Nanostructure Nanostructures - chemistry nanovalves Silicon dioxide Silicon Dioxide - chemistry stimuli-responsive nanoparticles
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Beschreibung
Zusammenfassung:	Molecular gates: A new approach in developing controlled drug‐delivery systems using aptamers as nanovalves is presented. For the proof of principle, mesoporous silica nanoparticles were modified with a hairpin form of ATP‐binding DNA, which allows encapsulation and release of guest molecules controlled by ATP. This reversible aptamer‐based nanogate function could provide novel trigger systems for any desired biological stimulus in drug‐delivery applications.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.201101403