Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen
Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2011-10, Vol.47 (37), p.10338-10340 |
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| container_issue | 37 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 47 |
| creator | Dai, Chaofeng Cazares, Lisa H Wang, Lifang Chu, Yong Wang, Siming L Troyer, Dean A Semmes, O John Drake, Richard R Wang, Binghe |
| description | Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate. |
| doi_str_mv | 10.1039/c1cc11814e |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2011-10, Vol.47 (37), p.10338-10340 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Boron Compounds - chemical synthesis Boron Compounds - metabolism Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Gene Expression Regulation, Neoplastic Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Lewis X Antigen - metabolism Molecular Imaging - methods Monosaccharides - chemical synthesis Monosaccharides - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods |
| title | Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen |
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