Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-10, Vol.47 (37), p.10338-10340
Hauptverfasser:	Dai, Chaofeng, Cazares, Lisa H, Wang, Lifang, Chu, Yong, Wang, Siming L, Troyer, Dean A, Semmes, O John, Drake, Richard R, Wang, Binghe
Format:	Artikel
Sprache:	eng
Schlagworte:	Boron Compounds - chemical synthesis Boron Compounds - metabolism Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Gene Expression Regulation, Neoplastic Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Lewis X Antigen - metabolism Molecular Imaging - methods Monosaccharides - chemical synthesis Monosaccharides - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c1cc11814e