Chemical analysis and study of immunoenhancing and antioxidant property of a glucan isolated from an alkaline extract of a somatic hybrid mushroom of Pleurotus florida and Calocybe indica variety APK2

A water-soluble glucan isolated from an alkaline extract of fruit bodies of a somatic hybrid mushroom PCH9FB of Pleurotus florida and Calocybe indica var. APK2 strains showed antioxidant properties with immune activation of macrophage, splenocyte, and thymocyte. On the basis of acid hydrolysis, meth...

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Veröffentlicht in:	International journal of biological macromolecules 2011-11, Vol.49 (4), p.555-560
Hauptverfasser:	Maity, Kousik, Kar (Mandal), Eshita, Maity, Saikat, Gantait, Sanjoy K., Das, Debsankar, Maiti, Swatilekha, Maiti, Tapas K., Sikdar, Samir R., Islam, Syed. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	acid hydrolysis Alkalies - chemistry Animals antioxidant activity Antioxidant property Antioxidants - pharmacology Calocybe carbon Cell Proliferation - drug effects chemical analysis Chemistry Techniques, Analytical - methods fruit extracts fruiting bodies Glucan glucans Glucans - chemical synthesis Glucans - immunology Glucans - isolation & purification Glucans - pharmacology Hybridization, Genetic hybrids Immunoactivation macrophage activation Macrophage Activation - drug effects Macrophages, Peritoneal - cytology Macrophages, Peritoneal - drug effects Magnetic Resonance Spectroscopy methylation Mice mushrooms Nitric Oxide - pharmacology NMR studies nuclear magnetic resonance spectroscopy oxidation Pleurotus - chemistry Pleurotus florida Somatic hybrid PCH9FB mushroom Spleen - cytology stable isotopes thymocytes Thymocytes - cytology Thymocytes - drug effects
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Zusammenfassung:	A water-soluble glucan isolated from an alkaline extract of fruit bodies of a somatic hybrid mushroom PCH9FB of Pleurotus florida and Calocybe indica var. APK2 strains showed antioxidant properties with immune activation of macrophage, splenocyte, and thymocyte. On the basis of acid hydrolysis, methylation, periodate oxidation and NMR studies (1H, 13C, DEPT-135, DQF-COSY, TOCSY, NOESY, ROESY, HMQC, and HMBC) the structure of the repeating unit of the glucan was established as: [Display omitted]
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2011.06.007