Final height (FH) in Turner syndrome (TS): experience of 76 cases followed at the Pediatric Endocrinology Unit, Hospital de Clinicas, Federal University of Paraná

To report the final height (FH) of 76 patients with Turner syndrome (TS). Review of the files and calculation of z scores: of target height (TH), and FH according to NCHS/CDC/2000 and FH according to Lyon and cols. Patients were classified in three groups: A (n = 16), treatment with estrogens and pr...

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Veröffentlicht in:Arquivos brasileiros de endocrinologia e metabologia 2011-06, Vol.55 (5), p.318-325
Hauptverfasser: Fonteles, Ana Vládia Ramos, Dondoni, Roberta Savaris, Boguszewski, Margaret Cristina da Silva, Nesi-França, Suzana, Marques-Pereira, Rosana, Sandrini Neto, Romolo, Lacerda Filho, Luiz de
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Zusammenfassung:To report the final height (FH) of 76 patients with Turner syndrome (TS). Review of the files and calculation of z scores: of target height (TH), and FH according to NCHS/CDC/2000 and FH according to Lyon and cols. Patients were classified in three groups: A (n = 16), treatment with estrogens and progestogens; B (n = 21), treatment with oxandrolone (OX); C (n = 39), growth hormone (GH) plus OX. The z score of TH was not different among the groups and z score of FH was not different between A e B. Z score of FH of group C was greater than the other groups, > 2SDS of Lyon's curve and fitted on the 3(rd) percentile of NCHS/CDC. Multiple regression analysis showed type of treatment (p < 0.001) and maternal height (p = 0.02) as most influencing factors on FH. GH plus OX and maternal height contributed significantly to enhance FH of TS patients.
ISSN:1677-9487
DOI:10.1590/S0004-27302011000500004