Flavusides A and B, Antibacterial Cerebrosides from the Marine-Derived Fungus Aspergillus flavus

Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and abs...

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Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2011/09/01, Vol.59(9), pp.1174-1177
Hauptverfasser: Yang, Guohua, Sandjo, Louis, Yun, Keumja, Leutou, Alain Simplice, Kim, Gun-Do, Choi, Hong Dae, Kang, Jung Sook, Hong, Jongki, Son, Byeng Wha
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Sprache:eng
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Zusammenfassung:Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 μg/ml for S. aureus and 31.2 μg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 μg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 μg/ml for multidrug-resistant S. aureus.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.59.1174