Application of Ring-Closing Metathesis for the Synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones

Cycloaddition reaction between toluamides and benzonitriles was applied to prepare the 3-arylisoquinolines, and their chemical transformation to the dienes 4 was performed. The ring-closing metathesis (RCM) reaction afforded the desired heterocyclic compounds, benzo[3,4]azepino[1,2-b]isoquinolinones...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2011/09/01, Vol.59(9), pp.1169-1173
Hauptverfasser:	Van, Hue Thi My, Khadka, Daulat Bikram, Le, Thanh Nguyen, Yang, Su Hui, Cho, Won-Jea
Format:	Artikel
Sprache:	eng
Schlagworte:	3-arylisoquinoline Amides - chemistry Benzazepines - chemical synthesis Benzazepines - chemistry benzo[3,4]azepino[1,2-b]isoquinolinone chemical shift difference Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Isoquinolines - chemical synthesis Isoquinolines - chemistry Magnetic Resonance Spectroscopy Molecular Conformation Nitriles - chemistry ring-closing metathesis
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