Application of Ring-Closing Metathesis for the Synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones

Application of Ring-Closing Metathesis for the Synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones

Cycloaddition reaction between toluamides and benzonitriles was applied to prepare the 3-arylisoquinolines, and their chemical transformation to the dienes 4 was performed. The ring-closing metathesis (RCM) reaction afforded the desired heterocyclic compounds, benzo[3,4]azepino[1,2-b]isoquinolinones...

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Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2011/09/01, Vol.59(9), pp.1169-1173
Hauptverfasser: Van, Hue Thi My, Khadka, Daulat Bikram, Le, Thanh Nguyen, Yang, Su Hui, Cho, Won-Jea
Format: Artikel
Sprache:eng
Schlagworte:
3-arylisoquinoline
Amides - chemistry
Benzazepines - chemical synthesis
Benzazepines - chemistry
benzo[3,4]azepino[1,2-b]isoquinolinone
chemical shift difference
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
Magnetic Resonance Spectroscopy
Molecular Conformation
Nitriles - chemistry
ring-closing metathesis
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Zusammenfassung:Cycloaddition reaction between toluamides and benzonitriles was applied to prepare the 3-arylisoquinolines, and their chemical transformation to the dienes 4 was performed. The ring-closing metathesis (RCM) reaction afforded the desired heterocyclic compounds, benzo[3,4]azepino[1,2-b]isoquinolinones 5 in good yield.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.59.1169