Kinetics of plasma SPB and RAGE during mechanical ventilation in patients undergoing major vascular surgery
Abstract Receptor-of-Advanced-Glycation-End-products (RAGE) and Surfactant-Protein-type-B (SPB) are reported as lung injury markers. Unlike SPB, RAGE is secreted by several tissues, so that RAGE specificity as lung injury marker is questionable. We measured SPB and RAGE in 19 patients undergoing maj...
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2011-09, Vol.178 (2), p.256-260 |
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| creator | Agostoni, Piergiuseppe Banfi, Cristina Magrì, Damiano Vignati, Carlo Doria, Elisabetta Salvioni, Elisabetta Moliterni, Paola Marenzi, Giancarlo Tremoli, Elena Sisillo, Erminio |
| description | Abstract Receptor-of-Advanced-Glycation-End-products (RAGE) and Surfactant-Protein-type-B (SPB) are reported as lung injury markers. Unlike SPB, RAGE is secreted by several tissues, so that RAGE specificity as lung injury marker is questionable. We measured SPB and RAGE in 19 patients undergoing major vascular abdominal surgery. SPB and RAGE were measured before mechanical ventilation ( T0 ), at 1st ( T1 ), 2nd ( T2 ) and, when present, 3rd ( T3 ) hour of mechanical ventilation, and 1 h after extubation ( TPOST ). Last data during mechanical ventilation, either T2 or T3 , are reported as TEND . SPB and RAGE values were normalized for total protein (SPBN and RAGEN ). SPBN and RAGEN increments from T0 to TEND were 56.2 [39.1] ng/mg (mean [75–25 percentile]) and 10.6[7.1] pg/mg, respectively. SPB values increased progressively during mechanical ventilation, whereas RAGE values increased at T1 but not thereafter. SPBN increase ( TEND − T0 ), but not RAGEN , was related to ΔPaO2 /FiO2 changes during mechanical ventilation ( r = 0.575, p = 0.01). Plasma RAGEN and SPBN kinetics in patients undergoing major vascular surgery are different. |
| doi_str_mv | 10.1016/j.resp.2011.06.019 |
| format | Article |
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Unlike SPB, RAGE is secreted by several tissues, so that RAGE specificity as lung injury marker is questionable. We measured SPB and RAGE in 19 patients undergoing major vascular abdominal surgery. SPB and RAGE were measured before mechanical ventilation ( T0 ), at 1st ( T1 ), 2nd ( T2 ) and, when present, 3rd ( T3 ) hour of mechanical ventilation, and 1 h after extubation ( TPOST ). Last data during mechanical ventilation, either T2 or T3 , are reported as TEND . SPB and RAGE values were normalized for total protein (SPBN and RAGEN ). SPBN and RAGEN increments from T0 to TEND were 56.2 [39.1] ng/mg (mean [75–25 percentile]) and 10.6[7.1] pg/mg, respectively. SPB values increased progressively during mechanical ventilation, whereas RAGE values increased at T1 but not thereafter. SPBN increase ( TEND − T0 ), but not RAGEN , was related to ΔPaO2 /FiO2 changes during mechanical ventilation ( r = 0.575, p = 0.01). Plasma RAGEN and SPBN kinetics in patients undergoing major vascular surgery are different.</description><identifier>ISSN: 1569-9048</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2011.06.019</identifier><identifier>PMID: 21736957</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acute Lung Injury - blood ; Acute Lung Injury - etiology ; Acute Lung Injury - pathology ; Aged ; Antigens, Neoplasm - blood ; Biological and medical sciences ; Biomarkers - blood ; Disease Progression ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Mechanical ventilation ; Medical Education ; Middle Aged ; Mitogen-Activated Protein Kinases - blood ; Mitogen-Activated Protein Kinases - pharmacokinetics ; Pulmonary Surfactant-Associated Protein B - blood ; Pulmonary Surfactant-Associated Protein B - pharmacokinetics ; Pulmonary/Respiratory ; Receptor for Advanced Glycation End Products ; Receptor of advanced glycation end products ; Receptors, Immunologic ; Respiration, Artificial - adverse effects ; Respiration, Artificial - standards ; Surfactant-protein-type-B ; Vascular surgery ; Vascular Surgical Procedures - adverse effects ; Vertebrates: respiratory system</subject><ispartof>Respiratory physiology & neurobiology, 2011-09, Vol.178 (2), p.256-260</ispartof><rights>Elsevier B.V.</rights><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. 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Unlike SPB, RAGE is secreted by several tissues, so that RAGE specificity as lung injury marker is questionable. We measured SPB and RAGE in 19 patients undergoing major vascular abdominal surgery. SPB and RAGE were measured before mechanical ventilation ( T0 ), at 1st ( T1 ), 2nd ( T2 ) and, when present, 3rd ( T3 ) hour of mechanical ventilation, and 1 h after extubation ( TPOST ). Last data during mechanical ventilation, either T2 or T3 , are reported as TEND . SPB and RAGE values were normalized for total protein (SPBN and RAGEN ). SPBN and RAGEN increments from T0 to TEND were 56.2 [39.1] ng/mg (mean [75–25 percentile]) and 10.6[7.1] pg/mg, respectively. SPB values increased progressively during mechanical ventilation, whereas RAGE values increased at T1 but not thereafter. SPBN increase ( TEND − T0 ), but not RAGEN , was related to ΔPaO2 /FiO2 changes during mechanical ventilation ( r = 0.575, p = 0.01). Plasma RAGEN and SPBN kinetics in patients undergoing major vascular surgery are different.</description><subject>Acute Lung Injury - blood</subject><subject>Acute Lung Injury - etiology</subject><subject>Acute Lung Injury - pathology</subject><subject>Aged</subject><subject>Antigens, Neoplasm - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical Education</subject><subject>Middle Aged</subject><subject>Mitogen-Activated Protein Kinases - blood</subject><subject>Mitogen-Activated Protein Kinases - pharmacokinetics</subject><subject>Pulmonary Surfactant-Associated Protein B - blood</subject><subject>Pulmonary Surfactant-Associated Protein B - pharmacokinetics</subject><subject>Pulmonary/Respiratory</subject><subject>Receptor for Advanced Glycation End Products</subject><subject>Receptor of advanced glycation end products</subject><subject>Receptors, Immunologic</subject><subject>Respiration, Artificial - adverse effects</subject><subject>Respiration, Artificial - standards</subject><subject>Surfactant-protein-type-B</subject><subject>Vascular surgery</subject><subject>Vascular Surgical Procedures - adverse effects</subject><subject>Vertebrates: respiratory system</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ksFu1DAQhiMEoqXwAhyQL4hTwkyyjm0JIZWqLYhKIApny-tMFqdZJ9jJSvv2dboLSBw4zcj6_pH9ebLsJUKBgPXbrggUx6IExALqAlA9yk5RCpkjR_U49bxWuYKVPMmexdgBoEBRPc1OylRqxcVpdvfZeZqcjWxo2dibuDXs9usHZnzDvp1fX7JmDs5v2JbsT-OdNT3bkZ9cbyY3eOY8G1OXTiKbfUNhMzzQphsC25lo594EFuewobB_nj1pTR_pxbGeZT-uLr9ffMxvvlx_uji_yS2HespFpQihXiMXShIoEtxaCRWZhmoupARhebWSpmkaUeFatFzKtmwVlFJiXVZn2ZvD3DEMv2aKk966aKnvjadhjlpKrqBKLhJZHkgbhhgDtXoMbmvCXiPoxbHu9OJYL4411Do5TqFXx_HzekvNn8hvqQl4fQSSANO3wXjr4l9ulZ4Jkifu3YGjJGPnKOhok0pLjQtkJ90M7v_3eP9P3Pbu4YvuaE-xG-bgk2aNOpYa9O2yDcsyIAKUVYnVPUWJrzs</recordid><startdate>20110915</startdate><enddate>20110915</enddate><creator>Agostoni, Piergiuseppe</creator><creator>Banfi, Cristina</creator><creator>Magrì, Damiano</creator><creator>Vignati, Carlo</creator><creator>Doria, Elisabetta</creator><creator>Salvioni, Elisabetta</creator><creator>Moliterni, Paola</creator><creator>Marenzi, Giancarlo</creator><creator>Tremoli, Elena</creator><creator>Sisillo, Erminio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110915</creationdate><title>Kinetics of plasma SPB and RAGE during mechanical ventilation in patients undergoing major vascular surgery</title><author>Agostoni, Piergiuseppe ; Banfi, Cristina ; Magrì, Damiano ; Vignati, Carlo ; Doria, Elisabetta ; Salvioni, Elisabetta ; Moliterni, Paola ; Marenzi, Giancarlo ; Tremoli, Elena ; Sisillo, Erminio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-739e106b15798e09e75cc803eade6578807c5348addd731b7f588f2f902881623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Lung Injury - blood</topic><topic>Acute Lung Injury - etiology</topic><topic>Acute Lung Injury - pathology</topic><topic>Aged</topic><topic>Antigens, Neoplasm - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medical Education</topic><topic>Middle Aged</topic><topic>Mitogen-Activated Protein Kinases - blood</topic><topic>Mitogen-Activated Protein Kinases - pharmacokinetics</topic><topic>Pulmonary Surfactant-Associated Protein B - blood</topic><topic>Pulmonary Surfactant-Associated Protein B - pharmacokinetics</topic><topic>Pulmonary/Respiratory</topic><topic>Receptor for Advanced Glycation End Products</topic><topic>Receptor of advanced glycation end products</topic><topic>Receptors, Immunologic</topic><topic>Respiration, Artificial - adverse effects</topic><topic>Respiration, Artificial - standards</topic><topic>Surfactant-protein-type-B</topic><topic>Vascular surgery</topic><topic>Vascular Surgical Procedures - adverse effects</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agostoni, Piergiuseppe</creatorcontrib><creatorcontrib>Banfi, Cristina</creatorcontrib><creatorcontrib>Magrì, Damiano</creatorcontrib><creatorcontrib>Vignati, Carlo</creatorcontrib><creatorcontrib>Doria, Elisabetta</creatorcontrib><creatorcontrib>Salvioni, Elisabetta</creatorcontrib><creatorcontrib>Moliterni, Paola</creatorcontrib><creatorcontrib>Marenzi, Giancarlo</creatorcontrib><creatorcontrib>Tremoli, Elena</creatorcontrib><creatorcontrib>Sisillo, Erminio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agostoni, Piergiuseppe</au><au>Banfi, Cristina</au><au>Magrì, Damiano</au><au>Vignati, Carlo</au><au>Doria, Elisabetta</au><au>Salvioni, Elisabetta</au><au>Moliterni, Paola</au><au>Marenzi, Giancarlo</au><au>Tremoli, Elena</au><au>Sisillo, Erminio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of plasma SPB and RAGE during mechanical ventilation in patients undergoing major vascular surgery</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2011-09-15</date><risdate>2011</risdate><volume>178</volume><issue>2</issue><spage>256</spage><epage>260</epage><pages>256-260</pages><issn>1569-9048</issn><eissn>1878-1519</eissn><abstract>Abstract Receptor-of-Advanced-Glycation-End-products (RAGE) and Surfactant-Protein-type-B (SPB) are reported as lung injury markers. Unlike SPB, RAGE is secreted by several tissues, so that RAGE specificity as lung injury marker is questionable. We measured SPB and RAGE in 19 patients undergoing major vascular abdominal surgery. SPB and RAGE were measured before mechanical ventilation ( T0 ), at 1st ( T1 ), 2nd ( T2 ) and, when present, 3rd ( T3 ) hour of mechanical ventilation, and 1 h after extubation ( TPOST ). Last data during mechanical ventilation, either T2 or T3 , are reported as TEND . SPB and RAGE values were normalized for total protein (SPBN and RAGEN ). SPBN and RAGEN increments from T0 to TEND were 56.2 [39.1] ng/mg (mean [75–25 percentile]) and 10.6[7.1] pg/mg, respectively. SPB values increased progressively during mechanical ventilation, whereas RAGE values increased at T1 but not thereafter. SPBN increase ( TEND − T0 ), but not RAGEN , was related to ΔPaO2 /FiO2 changes during mechanical ventilation ( r = 0.575, p = 0.01). Plasma RAGEN and SPBN kinetics in patients undergoing major vascular surgery are different.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21736957</pmid><doi>10.1016/j.resp.2011.06.019</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute Lung Injury - blood Acute Lung Injury - etiology Acute Lung Injury - pathology Aged Antigens, Neoplasm - blood Biological and medical sciences Biomarkers - blood Disease Progression Female Fundamental and applied biological sciences. Psychology Humans Male Mechanical ventilation Medical Education Middle Aged Mitogen-Activated Protein Kinases - blood Mitogen-Activated Protein Kinases - pharmacokinetics Pulmonary Surfactant-Associated Protein B - blood Pulmonary Surfactant-Associated Protein B - pharmacokinetics Pulmonary/Respiratory Receptor for Advanced Glycation End Products Receptor of advanced glycation end products Receptors, Immunologic Respiration, Artificial - adverse effects Respiration, Artificial - standards Surfactant-protein-type-B Vascular surgery Vascular Surgical Procedures - adverse effects Vertebrates: respiratory system |
| title | Kinetics of plasma SPB and RAGE during mechanical ventilation in patients undergoing major vascular surgery |
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