Kinetics of plasma SPB and RAGE during mechanical ventilation in patients undergoing major vascular surgery

Abstract Receptor-of-Advanced-Glycation-End-products (RAGE) and Surfactant-Protein-type-B (SPB) are reported as lung injury markers. Unlike SPB, RAGE is secreted by several tissues, so that RAGE specificity as lung injury marker is questionable. We measured SPB and RAGE in 19 patients undergoing major vascular abdominal surgery. SPB and RAGE were measured before mechanical ventilation ( T0 ), at 1st ( T1 ), 2nd ( T2 ) and, when present, 3rd ( T3 ) hour of mechanical ventilation, and 1 h after extubation ( TPOST ). Last data during mechanical ventilation, either T2 or T3 , are reported as TEND . SPB and RAGE values were normalized for total protein (SPBN and RAGEN ). SPBN and RAGEN increments from T0 to TEND were 56.2 [39.1] ng/mg (mean [75–25 percentile]) and 10.6[7.1] pg/mg, respectively. SPB values increased progressively during mechanical ventilation, whereas RAGE values increased at T1 but not thereafter. SPBN increase ( TEND − T0 ), but not RAGEN , was related to ΔPaO2 /FiO2 changes during mechanical ventilation ( r = 0.575, p = 0.01). Plasma RAGEN and SPBN kinetics in patients undergoing major vascular surgery are different.