Antibacterial Polyketides from the Jellyfish-Derived Fungus Paecilomyces variotii

Four new polyketides (1–4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. The co...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-08, Vol.74 (8), p.1826-1829
Hauptverfasser:	Liu, Juan, Li, Famei, Kim, Eun La, Li, Jian Lin, Hong, Jongki, Bae, Kyung Sook, Chung, Hae Young, Kim, Hyung Sik, Jung, Jee H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Benzofurans - chemistry Benzofurans - isolation & purification Benzofurans - pharmacology Biological and medical sciences Chemotherapic agents Drug Resistance, Multiple - drug effects Fundamental and applied biological sciences. Psychology Indans - chemistry Indans - isolation & purification Indans - pharmacology Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Microbiology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oceans and Seas Paecilomyces - chemistry Paecilomyces variotii Scyphozoa - microbiology Staphylococcus aureus Vibrio Vibrio parahaemolyticus - drug effects
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Beschreibung
Zusammenfassung:	Four new polyketides (1–4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. The compounds showed inhibitory activity against pathogenic bacteria including methicillin-resistant Staphylococcus aureus 3089 and multi-drug-resistant Vibrio parahemolyticus 7001 with MIC values in the range 5–40 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np200350b