A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis

A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis

In the current issue of Immunity, Martínez-Martín et al. (2011) describe the central supramolecular activation cluster (cSMAC) as a site of clathrin-independent T cell receptor (TCR) internalization and trogocytosis. Further, they identify small Rho GTPases TC21 and RhoG as key mediators of these pr...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2011-08, Vol.35 (2), p.151-153
Hauptverfasser: Dopfer, Elaine Pashupati, Minguet, Susana, Schamel, Wolfgang W.A.
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Immune system
Kinases
Proteins
T cell receptors
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Zusammenfassung:In the current issue of Immunity, Martínez-Martín et al. (2011) describe the central supramolecular activation cluster (cSMAC) as a site of clathrin-independent T cell receptor (TCR) internalization and trogocytosis. Further, they identify small Rho GTPases TC21 and RhoG as key mediators of these processes.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2011.08.004