Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione

The novel chrysin analog 8-bromo-7-methoxychrysin （BrMC） has been reported to induce apoptosis of various cancer cell lines. Arsenic trioxide （ATO） treatment induces clinical remission in acute promyelocytic leukemia patients. The combination of ATO with other agents has been shown to improve therap...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2011-09, Vol.43 (9), p.712-721
Hauptverfasser:	Xiao, Guangfen, Tang, Xueyuan, Yao, Chenjiao, Wang, Chenghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Antineoplastic Agents - pharmacology Apoptosis - drug effects Arsenicals - pharmacology bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism Blotting, Western Cell Survival - drug effects Cytochromes c - metabolism Dose-Response Relationship, Drug Drug Synergism Flavonoids - pharmacology Glutathione - metabolism Glutathione - pharmacology GSH含量 HL-60 Cells Humans Intracellular Space - drug effects Intracellular Space - metabolism Jurkat Cells Leukemia - metabolism Leukemia - pathology Mitochondria - drug effects Mitochondria - metabolism Oxides - pharmacology Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Time Factors U937 Cells X-Linked Inhibitor of Apoptosis Protein - metabolism 三氧化二砷人类急性早幼粒细胞白血病白血病细胞细胞内诱导凋亡还原型谷胱甘肽
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