Olanzapine Intoxication-Related Transient Diabetes Insipidus

Olanzapine Intoxication-Related Transient Diabetes Insipidus

Abstract Olanzapine is a second-generation atypical antipsychotic agent approved for the treatment of psychotic disorders and mania. The effects of olanzapine intoxication include central nervous system depression, hyperthermia, myosis, tachycardia, and orthostatic hypotension. Heretofore, only one...

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Veröffentlicht in:Renal failure 2011-09, Vol.33 (8), p.842-843
Hauptverfasser: Koçer, Emel, Alçelik, Aytekin, Canan, Fatih
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antipsychotic Agents - poisoning
Benzodiazepines - poisoning
diabetes insipidus
Diabetes Insipidus - chemically induced
Drug Overdose
Humans
intoxication
Male
olanzapine
polyuria
suicide
Time Factors
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Zusammenfassung:Abstract Olanzapine is a second-generation atypical antipsychotic agent approved for the treatment of psychotic disorders and mania. The effects of olanzapine intoxication include central nervous system depression, hyperthermia, myosis, tachycardia, and orthostatic hypotension. Heretofore, only one case has been reported to develop polyuria after olanzapine overdose (560 mg). We describe a case that developed diabetes insipidus following massive olanzapine ingestion and returned to normal after desmopressin treatment.
ISSN:0886-022X
1525-6049
DOI:10.3109/0886022X.2011.599094