Lack of correlation between BCG-induced tuberculin skin test sensitisation and protective immunity in cattle
Highlights ► The duration of BCG-induced tuberculin skin-test sensitisation was determined in neonatally vaccinated calves. ► BCG induced strong skin-test sensitisation in calves but this sensitisation waned rapidly after 6 months. ► Groups of BCG vaccinated calves that had lost or retained their sk...
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| Veröffentlicht in: | Vaccine 2011-07, Vol.29 (33), p.5453-5458 |
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| container_issue | 33 |
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| creator | Whelan, A.O Coad, M Upadhyay, B.L Clifford, D.J Hewinson, R.G Vordermeier, H.M |
| description | Highlights ► The duration of BCG-induced tuberculin skin-test sensitisation was determined in neonatally vaccinated calves. ► BCG induced strong skin-test sensitisation in calves but this sensitisation waned rapidly after 6 months. ► Groups of BCG vaccinated calves that had lost or retained their skin-test response after 6-months were challenged with M. bovis to investigate the relationship between skin-test sensitisation and vaccine induced protective immunity. ► Loss of BCG induced skin-test responsiveness did not result in loss of protective immunity against M. bovis infection. |
| doi_str_mv | 10.1016/j.vaccine.2011.05.057 |
| format | Article |
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Psychology ; Histopathology ; immunity ; interferon-gamma ; Interferon-gamma - secretion ; Leukocytes, Mononuclear - immunology ; Microbiology ; monitoring ; Mycobacterium bovis ; Pathology ; Skin ; Skin-test ; slaughter ; Studies ; Tuberculin ; Tuberculin Test ; Tuberculosis ; Tuberculosis, Bovine - immunology ; Tuberculosis, Bovine - prevention & control ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2011-07, Vol.29 (33), p.5453-5458</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Crown Copyright © 2011. Published by Elsevier Ltd. 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| ispartof | Vaccine, 2011-07, Vol.29 (33), p.5453-5458 |
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| subjects | Age Allergy and Immunology Animals Applied microbiology Bacteriology BCG BCG Vaccine - administration & dosage BCG Vaccine - immunology Biological and medical sciences blood Bovine tuberculosis calves Cattle DIVA Fundamental and applied biological sciences. Psychology Histopathology immunity interferon-gamma Interferon-gamma - secretion Leukocytes, Mononuclear - immunology Microbiology monitoring Mycobacterium bovis Pathology Skin Skin-test slaughter Studies Tuberculin Tuberculin Test Tuberculosis Tuberculosis, Bovine - immunology Tuberculosis, Bovine - prevention & control Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Lack of correlation between BCG-induced tuberculin skin test sensitisation and protective immunity in cattle |
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