Lack of correlation between BCG-induced tuberculin skin test sensitisation and protective immunity in cattle

Lack of correlation between BCG-induced tuberculin skin test sensitisation and protective immunity in cattle

Highlights ► The duration of BCG-induced tuberculin skin-test sensitisation was determined in neonatally vaccinated calves. ► BCG induced strong skin-test sensitisation in calves but this sensitisation waned rapidly after 6 months. ► Groups of BCG vaccinated calves that had lost or retained their sk...

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Veröffentlicht in:Vaccine 2011-07, Vol.29 (33), p.5453-5458
Hauptverfasser: Whelan, A.O, Coad, M, Upadhyay, B.L, Clifford, D.J, Hewinson, R.G, Vordermeier, H.M
Format: Artikel
Sprache:eng
Schlagworte:
Age
Allergy and Immunology
Animals
Applied microbiology
Bacteriology
BCG
BCG Vaccine - administration & dosage
BCG Vaccine - immunology
Biological and medical sciences
blood
Bovine tuberculosis
calves
Cattle
DIVA
Fundamental and applied biological sciences. Psychology
Histopathology
immunity
interferon-gamma
Interferon-gamma - secretion
Leukocytes, Mononuclear - immunology
Microbiology
monitoring
Mycobacterium bovis
Pathology
Skin
Skin-test
slaughter
Studies
Tuberculin
Tuberculin Test
Tuberculosis
Tuberculosis, Bovine - immunology
Tuberculosis, Bovine - prevention & control
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:Highlights ► The duration of BCG-induced tuberculin skin-test sensitisation was determined in neonatally vaccinated calves. ► BCG induced strong skin-test sensitisation in calves but this sensitisation waned rapidly after 6 months. ► Groups of BCG vaccinated calves that had lost or retained their skin-test response after 6-months were challenged with M. bovis to investigate the relationship between skin-test sensitisation and vaccine induced protective immunity. ► Loss of BCG induced skin-test responsiveness did not result in loss of protective immunity against M. bovis infection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.05.057