BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal
Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) modulate addictive behaviour. Therefore we investigated alterations in BDNF (81 male patients) and GDNF serum levels (52 male patients) in alcohol-dependent patients...
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Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2010-08, Vol.34 (6), p.1060-1064 |
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Sprache: | eng |
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Zusammenfassung: | Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) modulate addictive behaviour. Therefore we investigated alterations in BDNF (81 male patients) and GDNF serum levels (52 male patients) in alcohol-dependent patients during alcohol withdrawal (day 1, 7 and 14) in comparison to healthy controls (41 male controls).
BDNF serum levels were not significantly altered in alcohol-dependent patients compared to healthy controls (
p
=
0.685). GDNF serum levels were significantly reduced in the alcohol-dependent patients (
p
<
0.001). BDNF (
p
=
0.265) and GDNF (
p
=
0.255) serum levels did not change significantly during alcohol withdrawal. BDNF serum levels were significantly negatively associated with alcohol withdrawal severity on day 1 (CIWA-Ar score,
p
=
0.004). GDNF serum levels were significantly negatively associated with individual estimation of alcohol tolerance (SESA-XT score,
p
=
0.028). There was no further association with psychometric dimensions of alcohol withdrawal.
In conclusion we found that GDNF serum levels are significantly reduced in alcohol-dependent patients. GDNF serum levels were negatively associated with alcohol tolerance. Moreover BDNF serum levels were found to be associated with withdrawal severity. |
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ISSN: | 0278-5846 1878-4216 |
DOI: | 10.1016/j.pnpbp.2010.05.025 |