BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal

Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) modulate addictive behaviour. Therefore we investigated alterations in BDNF (81 male patients) and GDNF serum levels (52 male patients) in alcohol-dependent patients...

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Veröffentlicht in:Progress in neuro-psychopharmacology & biological psychiatry 2010-08, Vol.34 (6), p.1060-1064
Hauptverfasser: Heberlein, Annemarie, Muschler, Marc, Wilhelm, Julia, Frieling, Helge, Lenz, Bernd, Gröschl, Michael, Kornhuber, Johannes, Bleich, Stefan, Hillemacher, Thomas
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Sprache:eng
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Zusammenfassung:Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) modulate addictive behaviour. Therefore we investigated alterations in BDNF (81 male patients) and GDNF serum levels (52 male patients) in alcohol-dependent patients during alcohol withdrawal (day 1, 7 and 14) in comparison to healthy controls (41 male controls). BDNF serum levels were not significantly altered in alcohol-dependent patients compared to healthy controls ( p = 0.685). GDNF serum levels were significantly reduced in the alcohol-dependent patients ( p < 0.001). BDNF ( p = 0.265) and GDNF ( p = 0.255) serum levels did not change significantly during alcohol withdrawal. BDNF serum levels were significantly negatively associated with alcohol withdrawal severity on day 1 (CIWA-Ar score, p = 0.004). GDNF serum levels were significantly negatively associated with individual estimation of alcohol tolerance (SESA-XT score, p = 0.028). There was no further association with psychometric dimensions of alcohol withdrawal. In conclusion we found that GDNF serum levels are significantly reduced in alcohol-dependent patients. GDNF serum levels were negatively associated with alcohol tolerance. Moreover BDNF serum levels were found to be associated with withdrawal severity.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2010.05.025