MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest

Highlights ► Overexpression of miR-122 by adenovirus rendered HCC cell sensitive to chemotherapy. ► Treatment with miR122 and chemotherapy resulted in high accumulation of cells in G2/M. ► miR-122 downregulated expression of MDR related genes, Bcl-w and cyclin B1.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2011-11, Vol.310 (2), p.160-169
Hauptverfasser:	Xu, Yanmin, Xia, Feng, Ma, Leina, Shan, Juanjuan, Shen, Junjie, Yang, Zhi, Liu, Jia, Cui, Youhong, Bian, Xiuwu, Bie, Ping, Qian, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Antineoplastic Agents - pharmacology Apoptosis Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell growth Cell Line, Tumor Chemotherapy Cyclin G1 - biosynthesis Cyclin G1 - genetics doxorubicin Doxorubicin - pharmacology Drug resistance Drug Resistance, Neoplasm Gene expression Gene Expression Regulation, Neoplastic gene overexpression genes Genetic Vectors - administration & dosage Genetic Vectors - genetics Hematology, Oncology and Palliative Medicine Hep G2 Cells Hepatocellular carcinoma hepatoma Humans Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology MDR microRNA MicroRNA-122 MicroRNAs MicroRNAs - administration & dosage MicroRNAs - biosynthesis MicroRNAs - genetics pathogenesis vincristine Vincristine - pharmacology
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Beschreibung
Zusammenfassung:	Highlights ► Overexpression of miR-122 by adenovirus rendered HCC cell sensitive to chemotherapy. ► Treatment with miR122 and chemotherapy resulted in high accumulation of cells in G2/M. ► miR-122 downregulated expression of MDR related genes, Bcl-w and cyclin B1.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.06.027