Diabetes in pregnancy may differentially affect neonatal outcomes for twins and singletons
Diabet. Med. 28, 1068–1073 (2011) Aim We tested the hypothesis that diabetes in pregnancy may differentially affect neonatal outcomes in twin vs. singleton pregnancies. Methods In a retrospective cohort analysis of twins (n = 422 068) and singletons (n = 14 298 367) born in the USA from 1998 to 20...
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| container_title | Diabetic medicine |
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| creator | Luo, Z. C. Simonet, F. Wei, S. Q. Xu, H. Rey, E. Fraser, W. D. |
| description | Diabet. Med. 28, 1068–1073 (2011)
Aim We tested the hypothesis that diabetes in pregnancy may differentially affect neonatal outcomes in twin vs. singleton pregnancies.
Methods In a retrospective cohort analysis of twins (n = 422 068) and singletons (n = 14 298 367) born in the USA from 1998 to 2001, we evaluated the adjusted odds ratios of adverse neonatal outcomes comparing diabetic vs. non‐diabetic pregnancies, controlling for maternal characteristics. Primary outcomes include macrosomia (birthweight for gestational age > 90th percentile), congenital anomalies, low 5‐min Apgar score ( |
| doi_str_mv | 10.1111/j.1464-5491.2011.03366.x |
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Aim We tested the hypothesis that diabetes in pregnancy may differentially affect neonatal outcomes in twin vs. singleton pregnancies.
Methods In a retrospective cohort analysis of twins (n = 422 068) and singletons (n = 14 298 367) born in the USA from 1998 to 2001, we evaluated the adjusted odds ratios of adverse neonatal outcomes comparing diabetic vs. non‐diabetic pregnancies, controlling for maternal characteristics. Primary outcomes include macrosomia (birthweight for gestational age > 90th percentile), congenital anomalies, low 5‐min Apgar score (< 4) and neonatal death.
Results Diabetes in pregnancy was associated with a similarly increased risk of congenital anomalies (adjusted odds ratios 1.52 vs. 1.59) and smaller increased risks of preterm birth (adjusted odds ratios 1.27 vs. 1.49) and macrosomia (adjusted odds ratios 1.38 vs. 2.03) in twins vs. singletons, but reduced risks of low 5‐min Apgar score (adjusted odds ratio 0.74) and neonatal death (adjusted odds ratio 0.76) in twins but not singletons.
Conclusions Diabetes in pregnancy may differentially affect neonatal outcomes in twins and singletons, indicating a need for further studies to differentiate the effects by clinical subtypes of diabetes in pregnancy, and to consider/evaluate differential clinical management protocols of diabetes in multiple vs. singleton pregnancies.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2011.03366.x</identifier><identifier>PMID: 21679236</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>5-min Apgar score ; Adult ; Apgar Score ; Biological and medical sciences ; congenital anomalies ; diabetes in pregnancy ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fetal Growth Retardation - epidemiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant, Newborn ; Maternal Age ; Medical sciences ; neonatal death ; Parity ; Pregnancy ; Pregnancy in Diabetics - epidemiology ; Pregnancy Outcome - epidemiology ; Pregnancy, Multiple ; Retrospective Studies ; Twins ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>Diabetic medicine, 2011-09, Vol.28 (9), p.1068-1073</ispartof><rights>2011 The Authors. Diabetic Medicine © 2011 Diabetes UK</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. Diabetic Medicine © 2011 Diabetes UK.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4366-d8da8a66a5b697f9752df5f463a85149dda296b52e9ebfe6633c425ebb5b9cab3</citedby><cites>FETCH-LOGICAL-c4366-d8da8a66a5b697f9752df5f463a85149dda296b52e9ebfe6633c425ebb5b9cab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2011.03366.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2011.03366.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24428449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21679236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Z. C.</creatorcontrib><creatorcontrib>Simonet, F.</creatorcontrib><creatorcontrib>Wei, S. Q.</creatorcontrib><creatorcontrib>Xu, H.</creatorcontrib><creatorcontrib>Rey, E.</creatorcontrib><creatorcontrib>Fraser, W. D.</creatorcontrib><title>Diabetes in pregnancy may differentially affect neonatal outcomes for twins and singletons</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Diabet. Med. 28, 1068–1073 (2011)
Aim We tested the hypothesis that diabetes in pregnancy may differentially affect neonatal outcomes in twin vs. singleton pregnancies.
Methods In a retrospective cohort analysis of twins (n = 422 068) and singletons (n = 14 298 367) born in the USA from 1998 to 2001, we evaluated the adjusted odds ratios of adverse neonatal outcomes comparing diabetic vs. non‐diabetic pregnancies, controlling for maternal characteristics. Primary outcomes include macrosomia (birthweight for gestational age > 90th percentile), congenital anomalies, low 5‐min Apgar score (< 4) and neonatal death.
Results Diabetes in pregnancy was associated with a similarly increased risk of congenital anomalies (adjusted odds ratios 1.52 vs. 1.59) and smaller increased risks of preterm birth (adjusted odds ratios 1.27 vs. 1.49) and macrosomia (adjusted odds ratios 1.38 vs. 2.03) in twins vs. singletons, but reduced risks of low 5‐min Apgar score (adjusted odds ratio 0.74) and neonatal death (adjusted odds ratio 0.76) in twins but not singletons.
Conclusions Diabetes in pregnancy may differentially affect neonatal outcomes in twins and singletons, indicating a need for further studies to differentiate the effects by clinical subtypes of diabetes in pregnancy, and to consider/evaluate differential clinical management protocols of diabetes in multiple vs. singleton pregnancies.</description><subject>5-min Apgar score</subject><subject>Adult</subject><subject>Apgar Score</subject><subject>Biological and medical sciences</subject><subject>congenital anomalies</subject><subject>diabetes in pregnancy</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fetal Growth Retardation - epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>neonatal death</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - epidemiology</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnancy, Multiple</subject><subject>Retrospective Studies</subject><subject>Twins</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v0zAYgC0EYmXwF5AviFOy-CNOfOCAulGYypD4EBIX601iTy6J09mu1vx7nLUr1_liR34e59WDECZFTtK62OSEC56VXJKcFoTkBWNC5PtnaHG6eI4WRcVpxoqKnKFXIWyKglDJ5Et0RomoJGVigf5cWmh01AFbh7de3zpw7YQHmHBnjdFeu2ih7ycM6auN2OnRQYQej7vYjkMSzehxvLcuYHAdDtbd9jqOLrxGLwz0Qb857ufo16ern8vP2frb6svy4zpreRo66-oOahACykbIysiqpJ0pDRcM6pJw2XVApWhKqqVujBaCsZbTUjdN2cgWGnaO3h_e3frxbqdDVIMNre57SLPugqprTijlBU1kfSBbP4bgtVFbbwfwkyKFmsOqjZr7qbmfmsOqh7Bqn9S3x5_smkF3J_GxZALeHQEILfTGp442_Oc4pzXnMnEfDty97fX05AHU5der-ZT87ODbEPX-5IP_q0TFqlL9vlmp9VKsfny_XiX7H-bjpHU</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Luo, Z. C.</creator><creator>Simonet, F.</creator><creator>Wei, S. Q.</creator><creator>Xu, H.</creator><creator>Rey, E.</creator><creator>Fraser, W. D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Diabetes in pregnancy may differentially affect neonatal outcomes for twins and singletons</title><author>Luo, Z. C. ; Simonet, F. ; Wei, S. Q. ; Xu, H. ; Rey, E. ; Fraser, W. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4366-d8da8a66a5b697f9752df5f463a85149dda296b52e9ebfe6633c425ebb5b9cab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>5-min Apgar score</topic><topic>Adult</topic><topic>Apgar Score</topic><topic>Biological and medical sciences</topic><topic>congenital anomalies</topic><topic>diabetes in pregnancy</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fetal Growth Retardation - epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>neonatal death</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - epidemiology</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnancy, Multiple</topic><topic>Retrospective Studies</topic><topic>Twins</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Z. C.</creatorcontrib><creatorcontrib>Simonet, F.</creatorcontrib><creatorcontrib>Wei, S. Q.</creatorcontrib><creatorcontrib>Xu, H.</creatorcontrib><creatorcontrib>Rey, E.</creatorcontrib><creatorcontrib>Fraser, W. D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Z. C.</au><au>Simonet, F.</au><au>Wei, S. Q.</au><au>Xu, H.</au><au>Rey, E.</au><au>Fraser, W. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes in pregnancy may differentially affect neonatal outcomes for twins and singletons</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2011-09</date><risdate>2011</risdate><volume>28</volume><issue>9</issue><spage>1068</spage><epage>1073</epage><pages>1068-1073</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Diabet. Med. 28, 1068–1073 (2011)
Aim We tested the hypothesis that diabetes in pregnancy may differentially affect neonatal outcomes in twin vs. singleton pregnancies.
Methods In a retrospective cohort analysis of twins (n = 422 068) and singletons (n = 14 298 367) born in the USA from 1998 to 2001, we evaluated the adjusted odds ratios of adverse neonatal outcomes comparing diabetic vs. non‐diabetic pregnancies, controlling for maternal characteristics. Primary outcomes include macrosomia (birthweight for gestational age > 90th percentile), congenital anomalies, low 5‐min Apgar score (< 4) and neonatal death.
Results Diabetes in pregnancy was associated with a similarly increased risk of congenital anomalies (adjusted odds ratios 1.52 vs. 1.59) and smaller increased risks of preterm birth (adjusted odds ratios 1.27 vs. 1.49) and macrosomia (adjusted odds ratios 1.38 vs. 2.03) in twins vs. singletons, but reduced risks of low 5‐min Apgar score (adjusted odds ratio 0.74) and neonatal death (adjusted odds ratio 0.76) in twins but not singletons.
Conclusions Diabetes in pregnancy may differentially affect neonatal outcomes in twins and singletons, indicating a need for further studies to differentiate the effects by clinical subtypes of diabetes in pregnancy, and to consider/evaluate differential clinical management protocols of diabetes in multiple vs. singleton pregnancies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21679236</pmid><doi>10.1111/j.1464-5491.2011.03366.x</doi><tpages>6</tpages></addata></record> |
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| subjects | 5-min Apgar score Adult Apgar Score Biological and medical sciences congenital anomalies diabetes in pregnancy Endocrinopathies Feeding. Feeding behavior Female Fetal Growth Retardation - epidemiology Fundamental and applied biological sciences. Psychology Humans Infant, Newborn Maternal Age Medical sciences neonatal death Parity Pregnancy Pregnancy in Diabetics - epidemiology Pregnancy Outcome - epidemiology Pregnancy, Multiple Retrospective Studies Twins Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Diabetes in pregnancy may differentially affect neonatal outcomes for twins and singletons |
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