Unsymmetrical β-cyclodextrin-conjugated silicon(IV) phthalocyanines as highly potent photosensitisers for photodynamic therapy

A series of unsymmetrical silicon(IV) phthalocyanines with a permethylated β-cyclodextrin unit and a sugar or a diamino moiety as the axial substituents have been prepared. These compounds are highly photocytotoxic with IC(50) values as low as 21 nM, which is ca. sevenfold lower than those of the sy...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-09, Vol.47 (34), p.9657-9659
Hauptverfasser:	Lau, Janet T F, Lo, Pui-Chi, Tsang, Yee-Man, Fong, Wing-Ping, Ng, Dennis K P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Cyclodextrins - chemistry HT29 Cells Humans Indoles - chemistry Mice Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Photochemotherapy - methods Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Silicon - chemistry
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Beschreibung
Zusammenfassung:	A series of unsymmetrical silicon(IV) phthalocyanines with a permethylated β-cyclodextrin unit and a sugar or a diamino moiety as the axial substituents have been prepared. These compounds are highly photocytotoxic with IC(50) values as low as 21 nM, which is ca. sevenfold lower than those of the symmetrical bis(cyclodextrin) analogue.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c1cc13783b