A cool channel in cold transduction

A cool channel in cold transduction

Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system. Here, we review the biophysical properties, physiological r...

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Veröffentlicht in:Physiology (Bethesda, Md.) Md.), 2011-08, Vol.26 (4), p.273-285
Hauptverfasser: Latorre, Ramón, Brauchi, Sebastián, Madrid, Rodolfo, Orio, Patricio
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Calcium Channels - physiology
Cold Temperature
Humans
Signal Transduction
Thermosensing - physiology
TRPM Cation Channels - physiology
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Zusammenfassung:Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system. Here, we review the biophysical properties, physiological role, and near-membrane trafficking of this exciting polymodal ion channel.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00004.2011