Mass eradication of Helicobacter pylori : feasible and advisable?

Annual recurrence of H pylori infection is about 12% in developing countries.14 However, the most serious issue relates to development of bacterial resistance for not only H pylori but potentially many other bacteria. [...] we believe that although any public policy aimed at decreasing the prevalenc...

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Veröffentlicht in:	The Lancet (British edition) 2011-08, Vol.378 (9790), p.462-464
Hauptverfasser:	Mazzoleni, Luiz Edmundo, Francesconi, Carlos Fernando, Sander, Guilherme Becker
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage Amoxicillin - administration & dosage Amoxicillin - adverse effects Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Antibiotics Cancer Clarithromycin - administration & dosage Clarithromycin - adverse effects Developing countries Drug Administration Schedule Drug Therapy, Combination Drugs, Generic Feasibility Studies Female Generic drugs Health Policy - trends Helicobacter Infections - drug therapy Helicobacter Infections - economics Helicobacter pylori - drug effects Humans Industrialized nations Internal Medicine Lansoprazole Latin America - epidemiology LDCs Male Metronidazole - administration & dosage Mortality Proton Pump Inhibitors - administration & dosage Public policy Randomized Controlled Trials as Topic Stomach Neoplasms - microbiology Stomach Neoplasms - mortality Stomach Neoplasms - prevention & control
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Beschreibung
Zusammenfassung:	Annual recurrence of H pylori infection is about 12% in developing countries.14 However, the most serious issue relates to development of bacterial resistance for not only H pylori but potentially many other bacteria. [...] we believe that although any public policy aimed at decreasing the prevalence of H pylori infection could lead to reductions in gastric cancer and peptic ulcer, the risks associated with antibiotic use might represent an important limitation to such a strategy.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(11)61099-4