A Modular Synthesis of Salvileucalin B Structural Domains

A Modular Synthesis of Salvileucalin B Structural Domains

A modular strategy leading to the salvileucalin B core structure has been accomplished. The developed synthetic strategy featured a bioinspired intramolecular Diels–Alder reaction to construct domain “A”, REDOX chemistry to functionalize domain “B”, and a palladium-mediated cross-coupling to install...

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Veröffentlicht in:Organic letters 2011-08, Vol.13 (16), p.4410-4413
Hauptverfasser: Tseng, Chih-Chung, Ding, Hanfeng, Li, Ang, Guan, Yucui, Chen, David Y.-K
Format: Artikel
Sprache:eng
Schlagworte:
Diterpenes - chemical synthesis
Models, Molecular
Molecular Structure
Oxidation-Reduction
Palladium - chemistry
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Zusammenfassung:A modular strategy leading to the salvileucalin B core structure has been accomplished. The developed synthetic strategy featured a bioinspired intramolecular Diels–Alder reaction to construct domain “A”, REDOX chemistry to functionalize domain “B”, and a palladium-mediated cross-coupling to install domain “C”. This flexible approach should facilitate further chemical and biological investigations of this fascinating class of compounds.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol201748x