Modular Synthesis of Naphthothiophenes by Pd-Catalyzed Tandem Direct Arylation/Suzuki Coupling

Modular Synthesis of Naphthothiophenes by Pd-Catalyzed Tandem Direct Arylation/Suzuki Coupling

A short and highly modular three-step synthesis of a new class of substituted naphthothiophenes has been developed exploiting a Pd-catalyzed tandem direct arylation/Suzuki coupling transformation as the key step.

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Veröffentlicht in:Organic letters 2011-08, Vol.13 (16), p.4236-4239
Hauptverfasser: Nicolaus, Norman, Franke, Patrick T, Lautens, Mark
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Models, Molecular
Molecular Structure
Naphthols - chemistry
Palladium - chemistry
Thiophenes - chemical synthesis
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Beschreibung
Zusammenfassung:A short and highly modular three-step synthesis of a new class of substituted naphthothiophenes has been developed exploiting a Pd-catalyzed tandem direct arylation/Suzuki coupling transformation as the key step.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol201585a