Biosynthesis of Himastatin: Assembly Line and Characterization of Three Cytochrome P450 Enzymes Involved in the Post-tailoring Oxidative Steps

It's only natural: The biosynthetic pathway of himastatin from Streptomyces himastatinicus featuring unusual domain organizations is elucidated by genome scanning, generation of in‐frame gene deletion mutants, and complementation experiments. Three cytochrome P450s that catalyze novel post‐tail...

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-08, Vol.50 (34), p.7797-7802
Hauptverfasser:	Ma, Junying, Wang, Zhongwen, Huang, Hongbo, Luo, Minghe, Zuo, Dianguang, Wang, Bo, Sun, Aijun, Cheng, Yi-Qiang, Zhang, Changsheng, Ju, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	biosynthesis Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism cytochromes CC coupling Molecular Conformation natural products Oxidation-Reduction peptides Peptides, Cyclic - biosynthesis Peptides, Cyclic - chemistry Stereoisomerism
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Zusammenfassung:	It's only natural: The biosynthetic pathway of himastatin from Streptomyces himastatinicus featuring unusual domain organizations is elucidated by genome scanning, generation of in‐frame gene deletion mutants, and complementation experiments. Three cytochrome P450s that catalyze novel post‐tailoring oxidative reactions (see picture) are characterized.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201102305